Crystallomics Core (CC)

The CC is responsible for producing highly purified protein samples and diffraction quality crystals and passing the crystals to the Structure Determination Core. Since the main goal of JCSG is the determination of a large number of novel-fold structures involved in signaling, a wide variety of proteins, including extracellular, intracellular, and integral membrane, will have to be prepared and crystallized. Currently, the nanoliter-crystallization high throughput robotics system is capable of assembling 11,500 crystallization trials per day at the 40 nanoliter level, and commercial crystallization robots can perform at most 5,000 trials per day, thus enabling less protein to be required for crystallization trials. When finished, the second generation crystallization system will be able to perform 135,000 trials a day, thus allowing the Crystallomics Core to increase the number of experiments done in a day and while reducing the amount of proteins required per trial and increasing the probability for success.

To the left is a chart showing the portions of the project the Crystallomics Core is responsible for (which is shown in blue).

Below are the major institutions that form the Crystallomics Core.