The main purpose of the Bioinformatics Core (BIC) is to select the target for research. The goals of BIC are to develop complete high throughput technology for structural genomics beginning with high throughput computational selection of target proteins, followed by robotic expression and crystallization and fully automated data collection and structure solution. The bioinformatic infrastructure will link all of these functions so that full documentation of every stage of the process is available in the public domain. During the initial phases we shall be using the C. elegans genome as a prototype for genomic selection of target proteins. Ultimately, the strategies that we develop will be extended to other genomes. The long-term goals will be to select for proteins with unknown or low homology folds that are associated with signaling.
Click for more information about C. elegans or Thermotoga maritima.