This chart explains which C. elegans proteins are selected for testing. C. elegans was chosen as the initial target selection because the fully sequenced genome has been mostly annotated and is publicly available. Once the production system is operational, the Steering Committee will determine which eukaryotic genomes, including human, mouse, and Drosophila, will be included in the target selection process.
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The selected proteins must pass three filters. The first filter checks for the proper size. If the size of the protein falls within 7 to 80 kDa, the protein is passed on to the next filter, which checks for certain sequences. If the protein fits the proper sequence, it must pass the Protein Data Bank (PDB) Purge, which searches for already known proteins, thus reducing redundancy and time by not testing the same structures again and again. If the protein is unknown to the data bank, it has passed all three filters and is a protein that JCSG researches. If the protein failed any of these three test, it is automatically thrown out of testing.
Click on any area of uncertainty from the flowchart for an explanation. |