|Organization and Group Information|
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for more information about each Core group)
The Joint Center for Structural Genomics is funded by the National Institute of General Medical Sciences (NIGMS), as part of the second phase of the Protein Structure Initiative (PSI) of the National Institutes of Health. (U54 GM074898)
The JCSG is a multi-institutional consortium with major activities at The Scripps Research Institute (TSRI); the Genomics Institute of the Novartis Research Foundation (GNF); the University of California, San Diego (UCSD); the Sanford-Burnham Medical Research Institute (Sanford-Burnham); and the Stanford Synchrotron Radiation Lightsource (SSRL), SLAC National Accelerator Laboratory, at Stanford University.
To explore the expanding protein universe to find new challenges and opportunities to significantly contribute to new biology, chemistry and medicine through development of HT approaches to structural genomics.
To operate a robust HT protein structure determination pipeline as a large-scale production center for PSI-2. A major goal is to ensure that innovative high-throughput approaches are developed that advance not only structural genomics, but also structural biology in general, via investigation of large numbers of high-value structures that populate protein fold and family space and by increasing the efficiency of structure determination at substantially reduced cost.
The JCSG centralizes each core activity into single dedicated sites, each handling distinct, but interconnected objectives. This unique approach allows each specialized group to focus on its own area of expertise and provides well-defined interfaces among the groups. In addition, this approach addresses the requirements for the scalability needed to process large numbers of targets at a greatly reduced cost per target.
JCSG production groups are:
The JCSG is committed to a model that employs distributed local management and centralized coordination to establish a pipeline with fully functional large-scale production sites that are tightly integrated to ensure standardization of data, uniformity of communication interfaces, and synchronization of production schedules. The overall structure of the JCSG is designed to ensure the most efficient operation and data management that optimizes the use of resources and minimizes the cost per structure. This "factory"-like approach was developed in a scalable mode to enable the JCSG to easily adapt to changing goals and challenges, which importantly includes a learning environment to feed results back from prior experiments in order to increase productivity at each step in the process.