PSCA Target Info

TM0040;TM0040	Protein Sequence Comparative Analysis (PSCA)

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TM0040 TM0040 JCSG 281921 Crystal Fine Screen 03-MAR-06

Protein Sequence Information

TOPSAN

JCSG Internal annotations

ACCESSION	TM0040
DESCRIPTION	Dihydropteroate synthase.
ORGANISM	Thermotoga maritima
COMMENT

DR	UNIPROT; Q9WXP7_THEMA
DR	SPTR; Q9WXP7 (flat text); Q9WXP7 (good view)
DR	GenBank; AAD35134
DR	Pfam; PF00809; Pterin_bind;
DR	Interpro; IPR000489; Dhdropt_synth;
DR	Interpro; IPR006390; DHPS;
DR	PDB; 1AJZ; Highly similar; 13-MAY-98; DIHYDROPTEROATE SYNTHASE;
DR	PDB; 1AJ0; Highly similar; 20-MAY-98; DIHYDROPTEROATE SYNTHASE;
DR	PDB; 1AJ2; Highly similar; 20-MAY-98; DIHYDROPTEROATE SYNTHASE;
DR	PDB; 3TYU; Highly similar; 14-MAR-12; 7,8-DIHYDROPTEROATE SYNTHASE;
DR	PDB; 3TYZ; Highly similar; 14-MAR-12; 7,8-DIHYDROPTEROATE SYNTHASE;
DR	PDB; 3TZF; Highly similar; 14-MAR-12; 7,8-DIHYDROPTEROATE SYNTHASE;
DR	PDB; 3TZN; Highly similar; 14-MAR-12; 7,8-DIHYDROPTEROATE SYNTHASE;
DR	PDB; 1TWS; Highly similar; 14-SEP-04; DHPS, DIHYDROPTEROATE SYNTHASE;
DR	FFAS; 281921; Fold and function assignment.
DR	TVPC; TM0040; Homologs in PDB, JCSG and SG center.
DR	OVP; TM0040; Ortholog view popup.
DR	TPM; TM0040; Target PDB monitor.
DR	FSS; TM0040; Target function coverage.

PROPERTY

Residues: 278 aa
Molecule Weight: 31636.97 Dalton
Isoelectric Point: 5.27
Extinction Coefficient: 29910
Gravy Index: -.21
Number of Met residues: 10
Percentage of Met residues: 3.60 %
Number of Cys residues: 1
Percentage of Cys residues: 0.36 %

SEQUENCE  amino acids 278 aa
>TM0040  TM0040 dihydropteroate synthase (folP)
MVYTTPWNRKIEFGRTMVMGIINVTPDSFFADSRKQSVLEAVETAKKMIEEGADIIDVGG
MSTRPGSDPVDEEEELNRVIPVIRAIRSITDVPISVDTYRWRVALKALEAGADIVNDISG
YQFEPDIVRVVSENNVPYVLMHIKGTPKTMQENPHYEDVVKEIKEYFTEKIEYLKEKGVN
QIVLDPGIGFGKRYEDNLEILRRIDEFKELKLPILIGASRKSFIGITLGNVPPEERLEGT
LAVTAYCTMKGVDIIRVHDVLPNKRVIRMMEAILWQRL

CDS  cDNA 834 bp
   1 gtggtttaca caactccatg gaacagaaag atcgagtttg gaagaacgat ggttatggga    60
  61 ataataaacg tcacaccgga ctccttcttc gctgattcca gaaaacagag cgtactcgaa   120
 121 gcggtggaaa ccgcaaagaa gatgatagaa gaaggtgctg acataataga cgtgggagga   180
 181 atgtccaccc gtcccggatc agatcccgtc gatgaggaag aagaattgaa cagagtgatt   240
 241 cccgtgataa gagcgatcag atcgataacc gacgttccga tttccgtaga tacatacagg   300
 301 tggagggtgg ctttgaaagc tcttgaagcc ggagcggata tcgtaaacga tatcagcggt   360
 361 tatcaattcg aaccggatat cgtcagagta gtttctgaaa acaacgtccc ttacgttctc   420
 421 atgcacataa aaggaacgcc aaagacgatg caggaaaatc ctcattacga agatgtggtg   480
 481 aaggagataa aagagtactt cacagaaaaa atagagtatc taaaagaaaa aggtgtgaac   540
 541 cagatcgttc tggacccggg tatcgggttt ggaaaaagat acgaagacaa cctcgaaatt   600
 601 cttcgaagga tcgacgaatt caaagagtta aaactgccca tcctcatagg tgcttcaaga   660
 661 aaatctttca taggaatcac cttgggaaac gtgccccccg aagaaagact tgaaggtact   720
 721 cttgcggtca ccgcgtactg cacgatgaaa ggagtagata taattcgggt acacgatgtc   780
 781 ctccctaaca agagggtgat aagaatgatg gaggcgatac tctggcaaag gttg   834

Warning: the change of start codon from ATG/M to GTG/V;
Target constructs
Download sequence in PIR or FASTA format
Chemical properties of sequence with tag

GENE PREDICTION

LEFT END	RIGHT END	FRAME	PREDICTOR	SCORE
39643	40479	1	Glimmer3 score	11.61	poor
			Genemark probabilities	.93 .99	good
			GenemarkHMM class	1	good

Notes

The start codon is a ATG/Methionine in most of sequences, but the GTG/V, TTG/L, CTG/I can be the start codons in some cases as expressing in E.coli. The start codon warning is labelled by RED color in sequence(sample: 10174951).

Protein sequence information contains the annotation contents from both of JCSG and SWISS-PROT. The SWISS-PROT/TrEMBL annotation is accessed from SWALL(SPTR) on the EBI SRS server. PDB homologes show both identical and highly similar proteins with released date and protein function.

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