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   TM1099;TM1099
Protein Sequence Comparative Analysis   (PSCA)
 
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TM1099    TM1099            JCSG 282965 Protein Purification 03-NOV-26

Protein Sequence Information


TOPSAN
JCSG Internal annotations

ACCESSIONTM1099
DESCRIPTIONThymidylate kinase (EC 2.7.4.9) (dTMP kinase).
ORGANISMThermotoga maritima
COMMENT-!- FUNCTION: PHOSPHORYLATION OF DTMP TO FORM DTDP IN BOTH DE NOVO AND
SALVAGE PATHWAYS OF DTTP SYNTHESIS (BY SIMILARITY).
-!- CATALYTIC ACTIVITY: ATP + THYMIDINE 5'-PHOSPHATE = ADP + THYMIDINE
5'-DIPHOSPHATE.
-!- SIMILARITY: BELONGS TO THE THYMIDYLATE KINASE FAMILY.
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DR UNIPROT; KTHY_THEMA
DR SPTR; Q9X0I3 (flat text); Q9X0I3 (good view)
DR GenBank; AAD36175
DR Pfam; PF02223; Thymidylate_kin;
DR Interpro; IPR000062; Thymidylate_kin;
DR PDB; 3HJN; Identical; 02-JUN-09; THYMIDYLATE KINASE;
DR PDB; 2PBR; Highly similar; 02-OCT-07; THYMIDYLATE KINASE;
DR PDB; 3LD9; Highly similar; 16-FEB-10; THYMIDYLATE KINASE;
DR PDB; 4E5U; Highly similar; 28-MAR-12; THYMIDYLATE KINASE;
DR PDB; 4EDH; Highly similar; 23-MAY-12; THYMIDYLATE KINASE;
DR PDB; 4ESH; Highly similar; 23-MAY-12; THYMIDYLATE KINASE;
DR PDB; 4GMD; Highly similar; 29-AUG-12; THYMIDYLATE KINASE;
DR PDB; 3UWO; Highly similar; 01-FEB-12; THYMIDYLATE KINASE;
DR KEGG; 2.7.4.9; Enzyme page
DR FFAS; 282965; Fold and function assignment.
DR TVPC; TM1099; Homologs in PDB, JCSG and SG center.
DR OVP; TM1099; Ortholog view popup.
DR TPM; TM1099; Target PDB monitor.
DR FSS; TM1099; Target function coverage.
PROPERTY Residues: 197 aa
Molecule Weight: 22848.08 Dalton
Isoelectric Point: 5.91
Extinction Coefficient: 15930
Gravy Index: -.42
Number of Met residues: 1
Percentage of Met residues: 0.51 %
Number of Cys residues: 0
Percentage of Cys residues: 0.00 %
SEQUENCE  amino acids 197 aa
>TM1099  TM1099 thymidylate kinase (tmk)
MFITFEGIDGSGKSTQIQLLAQYLEKRGKKVILKREPGGTETGEKIRKILLEEEVTPKAE
LFLFLASRNLLVTEIKQYLSEGYAVLLDRYTDSSVAYQGFGRNLGKEIVEELNDFATDGL
IPDLTFYIDVDVETALKRKGELNRFEKREFLERVREGYLVLAREHPERIVVLDGKRSIEE
IHRDVVREVKRRWKLDV

CDS  cDNA 591 bp
   1 atgttcataa cgttcgaggg aatagacgga tccgggaaga gcacacagat ccaacttctg    60
  61 gctcaatacc tggagaagag aggaaagaaa gtgatcttga agagagagcc gggcggaacg   120
 121 gagacggggg agaagatcag aaagattctt ctggaggaag aagtgactcc caaagctgag   180
 181 ctcttcctgt ttctcgcctc gagaaatctc cttgtgacag aaataaaaca gtacctttcc   240
 241 gaaggatacg ccgttcttct tgacagatac acggactcca gtgttgcata ccagggtttt   300
 301 ggaagaaacc tgggaaaaga gatcgtggag gagctgaacg atttcgccac ggatggactg   360
 361 attcctgacc tgactttcta catagacgtg gacgtcgaaa cggccctcaa aagaaaagga   420
 421 gagctcaacc gctttgaaaa aagagagttt ctcgaacgtg taagggaagg ctacctcgtg   480
 481 ctcgccagag aacatcccga aaggatcgtg gtgctggatg gaaaacgctc catagaggaa   540
 541 atccacaggg acgtggtgag ggaagttaaa agaaggtgga aactcgatgt t   591
Target constructs
Download sequence in PIR or FASTA format
Chemical properties of sequence with tag
GENE PREDICTION
LEFT END RIGHT END FRAME PREDICTOR SCORE 
1116458 1117051 2 Glimmer3 score - -
Genemark probabilities .87   .93 good
GenemarkHMM class - -

Notes

The start codon is a ATG/Methionine in most of sequences, but the GTG/V, TTG/L, CTG/I can be the start codons in some cases as expressing in E.coli. The start codon warning is labelled by RED color in sequence(sample: 10174951).

Protein sequence information contains the annotation contents from both of JCSG and SWISS-PROT. The SWISS-PROT/TrEMBL annotation is accessed from SWALL(SPTR) on the EBI SRS server. PDB homologes show both identical and highly similar proteins with released date and protein function.


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